Protein Modification Reagents
Medchemexpress LLC (S,R,S)-AHPC-PEG2-C4-CI | 1835705-57-1 | MFCD31560480 | ≥98.0% | 651.26 g/mol | C32H47ClN4O6S | 50 MG
(S,R,S)-AHPC-PEG2-C4-Cl is a VHL ligand-linker conjugate used as a building block in PROTAC and targeted protein degradation research. It features an (S,R,S)-configured AHPC VHL ligand linked via a PEG2-C4 spacer to a terminal chloride, typically supplied as a light yellow oil and provided at high purity for chemical biology applications.
- Includes a PEG2-C4 linker with a terminal chloride for conjugation
- Contains an (S,R,S)-configured AHPC VHL ligand moiety
- High purity suitable for synthesis and biological assays (≥98.0%)
- Molecular weight 651.26 g/mol; formula C32H47ClN4O6S
- Supplied as an oil; handle and store per safety data sheet
Creative Pegworks mPEG-OH, MW 2k | 9004-74-4 | MFCD00084416 | 50g
mPEG-OH, MW 2k | 9004-74-4 | MFCD00084416 | 50g
Medchemexpress LLC Gly-gly-gly-PEG4-DBCO | 2353409-80-8 | 694.77 | C35H46N6O9 | 50 MG
Gly-Gly-Gly-PEG4-DBCO is a four-unit polyethylene glycol (PEG) linker bearing a dibenzocyclooctyne (DBCO) reactive group used for bioconjugation and copper-free click chemistry (strain-promoted alkyne-azide cycloaddition, SPAAC) to couple azide-containing molecules. Typically used in antibody-drug conjugate linker synthesis and site-specific conjugation.
- Four-unit PEG spacer improves solubility and flexibility.
- DBCO group enables copper-free SPAAC click reactions with azides.
- Supplied in small-scale quantities suitable for research use.
- Characterized by molecular formula C35H46N6O9 and molecular weight 694.77.
Medchemexpress LLC (S,R,S)-AHPC-PEG1-N3 | 2101200-09-1 | MFCD31807301 | 98.8% | 557.67 g/mol | C26H35N7O5S | 2 G
(S,R,S)-AHPC-PEG1-N3 is an azide-functionalized von Hippel-Lindau (VHL) ligand-linker conjugate used as a click chemistry reagent to attach VHL-binding modules to other molecules in PROTAC design and chemical biology studies. It contains a PEG1 spacer and a terminal azide for copper-catalyzed azide-alkyne cycloaddition, and is supplied as a solid with defined purity and molecular weight.
- Azide terminal for copper-catalyzed click chemistry.
- Peg1 spacer provides a short, flexible linker.
- VHL ligand enables E3 ligase recruitment in conjugates.
- High purity and characterized molecular weight for reproducible coupling.
- Solid, white to light yellow, with recommended cold storage for stability.
- Available in gram-scale pack sizes for synthesis and optimization workflows.
Cayman Chemical PomalIdomIde 4-PEG5-amInh 50mg
A PEGylated form of pomalidomide; has been conjugated to various ligands in the development of PROTACs
eMolecules Fmoc-N-amido-PEG20-acid | 1952360-93-8 | MFCD21363316 | 1g
Broadpharm | Fmoc-N-amido-PEG20-acid | 1g | 296213777 | BP-22035 | 97.000 | 1952360-93-8 | MFCD21363316 | 1192.397 | C58H97NO24
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eMolecules DBCO-PEG4-alcohol | 1416711-60-8 | | 500mg
Broadpharm | DBCO-PEG4-alcohol | 500mg | 296213666 | BP-22800 | 95.000 | 1416711-60-8 | | 508.615 | C29H36N2O6
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eMolecules Amino-PEG24-t-butyl ester | 872340-65-3 | MFCD11041158 | 1g
Broadpharm | Amino-PEG24-t-butyl ester | 1g | 272384125 | BP-21920 | 97.000 | 872340-65-3 | MFCD11041158 | 1202.474 | C55H111NO26
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![Medchemexpress LLC Acetamide 2-(2-aminoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]HCl | 2380273-67-4 | 97.1% | 410.81 g/mol | C17H19ClN4O6 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221842.png-250.jpg)
Medchemexpress LLC Acetamide 2-(2-aminoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]HCl | 2380273-67-4 | 97.1% | 410.81 g/mol | C17H19ClN4O6 | 5 MG
Pomalidomide-PEG1-NH2 hydrochloride is a pomalidomide-based E3 ligase ligand-linker conjugate (hydrochloride salt) featuring a short PEG linker terminated in a primary amine. It is designed for use in targeted protein degradation chemistry as a cereblon-recruiting ligand and for covalent coupling to target ligands via the terminal amine.
- Primary amine-terminated PEG1 linker for conjugation to carboxyl groups.
- E3 ligase (cereblon) recruiter based on a pomalidomide scaffold.
- Supplied as a hydrochloride salt for improved stability and handling.
- High purity (~97%) suitable for research and medicinal chemistry.
- Available in multiple small-mass package sizes for synthesis work.
eMolecules Amino-PEG10-amine | 928292-69-7 | MFCD28122962 | 1g
Broadpharm | Amino-PEG10-amine | 1g | 254745494 | BP-22253 | 98.000 | 928292-69-7 | MFCD28122962 | 500.630 | C22H48N2O10
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eMolecules DNP-PEG12-NHS ester | 1334178-01-6 | MFCD13185013 | 1g
Broadpharm | DNP-PEG12-NHS ester | 1g | 550804147 | BP-22397 | 98.000 | 1334178-01-6 | MFCD13185013 | 880.895 | C37H60N4O20
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![eMolecules Broadpharm / Desthiobiotin-PEG3-Azide / 5mg / 713699521 / BP-22473 / 98.000 / 1426828-06-9 / [null] / 414.507 / C18H34N6O5](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502454940.PNG-250.jpg)
eMolecules Broadpharm / Desthiobiotin-PEG3-Azide / 5mg / 713699521 / BP-22473 / 98.000 / 1426828-06-9 / [null] / 414.507 / C18H34N6O5
Broadpharm / Desthiobiotin-PEG3-Azide / 5mg / 713699521 / BP-22473 / 98.000 / 1426828-06-9 / [null] / 414.507 / C18H34N6O5
Medchemexpress LLC Dspe-peg-fitc | 1000788-53-3 | 90.3% | 3400 (average) | 50 MG
DSPE-PEG-FITC (MW 3400) is a fluorescein-labeled PEGylated phospholipid for incorporation into liposomes, nanoparticles, membranes, or cells to enable fluorescence detection and tracking in research applications.
- Provides a hydrophobic phospholipid anchor for stable incorporation into lipid bilayers and particles.
- PEG spacer reduces non-specific interactions and improves colloidal stability.
- Terminal fluorescein (FITC) enables fluorescence imaging and flow cytometry; absorption ~494 nm, emission ~520 nm.
- Average molecular weight approximately 3,400 for a defined spacer length.
- Documentation available including data sheet, COA, and SDS for quality and safety information.
Medchemexpress LLC Dota-PEG5-amine | 00-00-0 | 98.0% | C28H54N6O12 | 10MG
DOTA-PEG5-amine is a polyethylene glycol (PEG)-based linker incorporating a DOTA chelator and a terminal primary amine. It is intended for use in the synthesis of PROTACs and other conjugates where a chelation site and a reactive amine are required; supplied as a white to off-white solid, characterized by molecular formula C28H54N6O12 and molecular weight 666.76 g·mol⁻¹.
- PEG-based linker with a terminal amine.
- Contains a DOTA chelator suitable for metal ion binding and radiolabeling.
- High purity (98.0%) appropriate for synthetic applications.
- Available in multiple small pack sizes for research use.
- Stable as a powder with defined storage conditions for long-term and short-term storage.